Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels

Diabetes mellitus is a well-known risk factor for pancreatic cancer. We focused on hyperglycemia, a main feature of diabetes mellitus, and uncovered its effect on precancerous pancreatic intraepithelial neoplasia (PanIN) progression. In vivo induction of hyperglycemia with 100 mg/kg streptozotocin i...

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Vydáno v:PLoS One
Hlavní autoři: Sato, Katsuhiko, Hikita, Hayato, Myojin, Yuta, Fukumoto, Kenji, Murai, Kazuhiro, Sakane, Sadatsugu, Tamura, Takeshi, Yamai, Takuo, Nozaki, Yasutoshi, Yoshioka, Teppei, Kodama, Takahiro, Shigekawa, Minoru, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329089/
https://ncbi.nlm.nih.gov/pubmed/32609742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235573
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