Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration

Hepatocellular carcinoma highly occurs in chronic hepatitis livers, where hepatocyte apoptosis is frequently detected. Apoptosis is a mechanism that eliminates mutated cells. Hepatocyte apoptosis induces compensatory liver regeneration, which is believed to contribute to tumor formation. Hepatocyte-...

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Udgivet i:Sci Rep
Main Authors: Nozaki, Yasutoshi, Hikita, Hayato, Tanaka, Satoshi, Fukumoto, Kenji, Urabe, Makiko, Sato, Katsuhiko, Myojin, Yuta, Doi, Akira, Murai, Kazuhiro, Sakane, Sadatsugu, Saito, Yoshinobu, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873060/
https://ncbi.nlm.nih.gov/pubmed/33564095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83082-7
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