Studies on the Stability and Stabilization of trans-Cyclooctenes through Radical Inhibition and Silver (I) Metal Complexation

Conformationally strained trans-cyclooctenes (TCOs) engage in bioorthogonal reactions with tetrazines with second order rate constants that can exceed 10(6) M(−1)s(−1). The goal of this study was to provide insight into the stability of TCO reagents and to develop methods for stabilizing TCO reagent...

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Veröffentlicht in:Tetrahedron
Hauptverfasser: Fang, Yinzhi, Judkins, Joshua C., Boyd, Samantha J., am Ende, Christopher W., Rohlfing, Katarina, Huang, Zhen, Xie, Yixin, Johnson, Douglas S., Fox, Joseph M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328862/
https://ncbi.nlm.nih.gov/pubmed/32612312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2019.05.038
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