UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent R-loop accumulation. One mechanism relies on the conserved THO complex in association with cotranscriptional RNA processing factors including the RNA-dependent ATPase UAP56/DDX39B...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Pérez-Calero, Carmen, Bayona-Feliu, Aleix, Xue, Xiaoyu, Barroso, Sonia I., Muñoz, Sergio, González-Basallote, Víctor M., Sung, Patrick, Aguilera, Andrés
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328515/
https://ncbi.nlm.nih.gov/pubmed/32439635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.336024.119
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