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TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2
In >95% of cases of amyotrophic lateral sclerosis (ALS) and ∼45% of frontotemporal degeneration (FTD), the RNA/DNA-binding protein TDP-43 is cleared from the nucleus and abnormally accumulates in the cytoplasm of affected brain cells. Although the cellular triggers of disease pathology remain eni...
Guardat en:
| Publicat a: | J Cell Sci |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Company of Biologists Ltd
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7328137/ https://ncbi.nlm.nih.gov/pubmed/32409565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.245811 |
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