B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α production

Rheumatoid arthritis (RA) is characterized by the production of anti-citrullinated protein antibodies (ACPAs). To gain insights into the relationship between ACPA-expressing B cells in peripheral blood (PB) and synovial tissue (ST), we sequenced the B cell repertoire in paired PB and ST samples from...

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Veröffentlicht in:Clin Immunol
Hauptverfasser: Elliott, Serra E., Kongpachith, Sarah, Lingampalli, Nithya, Adamska, Julia Z., Cannon, Bryan J., Blum, Lisa K., Bloom, Michelle S., Henkel, Matthew, McGeachy, Mandy J., Moreland, Larry W., Robinson, William H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327984/
https://ncbi.nlm.nih.gov/pubmed/32035179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2020.108360
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