Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains

Seasonal influenza vaccines elicit antibody responses that can prevent infection, but their efficacy is reduced in the elderly. While a subset of elderly individuals can still mount sufficient vaccine-induced antibody responses, little is known about the properties of the vaccine-induced antibody re...

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Udgivet i:Clin Immunol
Main Authors: Ju, Chia-Hsin, Blum, Lisa K., Kongpachith, Sarah, Lingampalli, Nithya, Mao, Rong, Brodin, Petter, Dekker, Cornelia L., Davis, Mark M., Robinson, William H.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026060/
https://ncbi.nlm.nih.gov/pubmed/29410330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2018.01.011
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