Tet3 regulates cellular identity and DNA methylation in neural progenitor cells

TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), a process thought to be intermediary in an active DNA demethylation mechanism. Notably, 5hmC is highly abundant in the brain and in neuronal cells. Here, we interrogated the function of Tet3 in neural precursor cells (NP...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Santiago, Mafalda, Antunes, Claudia, Guedes, Marta, Iacovino, Michelina, Kyba, Michael, Reik, Wolf, Sousa, Nuno, Pinto, Luísa, Branco, Miguel R., Marques, C. Joana
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326798/
https://ncbi.nlm.nih.gov/pubmed/31646359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03335-7
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