Tet3 regulates cellular identity and DNA methylation in neural progenitor cells

TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), a process thought to be intermediary in an active DNA demethylation mechanism. Notably, 5hmC is highly abundant in the brain and in neuronal cells. Here, we interrogated the function of Tet3 in neural precursor cells (NP...

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Vydáno v:Cell Mol Life Sci
Hlavní autoři: Santiago, Mafalda, Antunes, Claudia, Guedes, Marta, Iacovino, Michelina, Kyba, Michael, Reik, Wolf, Sousa, Nuno, Pinto, Luísa, Branco, Miguel R., Marques, C. Joana
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326798/
https://ncbi.nlm.nih.gov/pubmed/31646359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03335-7
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