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A Synthetic Reporter for Probing Mistranslation in Living Cells

Aminoacyl-tRNA synthetases (AARSs) play key roles in maintaining high fidelity of protein synthesis. They charge cognate tRNAs with corresponding amino acids and hydrolyze mischarged tRNAs by editing mechanisms. Impairment of AARS editing activities can reduce the accuracy of tRNA aminoacylation to...

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Detalles Bibliográficos
Publicado en:Front Bioeng Biotechnol
Main Authors: Chen, Hao, Ercanbrack, Carson, Wang, Tony, Gan, Qinglei, Fan, Chenguang
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326783/
https://ncbi.nlm.nih.gov/pubmed/32671035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00623
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