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A dual fluorescent reporter for the investigation of methionine mistranslation in live cells
In mammalian cells under oxidative stress, the methionyl-tRNA synthetase (MetRS) misacylates noncognate tRNAs at frequencies as high as 10% distributed among up to 28 tRNA species. Instead of being detrimental for the cell, misincorporation of methionine residues in the proteome reduces the risk of...
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| Publicado no: | RNA |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4748823/ https://ncbi.nlm.nih.gov/pubmed/26729921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.054163.115 |
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