Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71

PURPOSE: To study the potential effect of a gene therapy, designed to rescue the expression of dystrophin Dp71 in the retinas of Dp71-null mice, on retinal physiology. METHODS: We recorded electroretinograms (ERGs) in Dp71-null and wild-type littermate mice. In dark-adapted eyes, responses to flashe...

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Enregistré dans:
Détails bibliographiques
Publié dans:Invest Ophthalmol Vis Sci
Auteurs principaux: Barboni, Mirella Telles Salgueiro, Vaillend, Cyrille, Joachimsthaler, Anneka, Liber, André Maurício Passos, Khabou, Hanen, Roux, Michel J., Vacca, Ophélie, Vignaud, Lucile, Dalkara, Deniz, Guillonneau, Xavier, Ventura, Dora Fix, Rendon, Alvaro, Kremers, Jan
Format: Artigo
Langue:Inglês
Publié: The Association for Research in Vision and Ophthalmology 2020
Sujets:
Visual Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326481/
https://ncbi.nlm.nih.gov/pubmed/32049345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.2.11
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