Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria

INTRODUCTION: Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiated epithelial cells of the glomerulus and the critical compo...

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Detalhes bibliográficos
Publicado no:BMJ Open Diabetes Res Care
Main Authors: Nishad, Rajkishor, Meshram, Prajakta, Singh, Ashish Kumar, Reddy, G Bhanuprakash, Pasupulati, Anil Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Pathophysiology/Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326296/
https://ncbi.nlm.nih.gov/pubmed/32601154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjdrc-2020-001203
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