Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria

INTRODUCTION: Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiated epithelial cells of the glomerulus and the critical compo...

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Dades bibliogràfiques
Publicat a:BMJ Open Diabetes Res Care
Autors principals: Nishad, Rajkishor, Meshram, Prajakta, Singh, Ashish Kumar, Reddy, G Bhanuprakash, Pasupulati, Anil Kumar
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2020
Matèries:
Pathophysiology/Complications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326296/
https://ncbi.nlm.nih.gov/pubmed/32601154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjdrc-2020-001203
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