Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria

Podocytes are specialized cells of the glomerulus and key component of the glomerular filtration apparatus (GFA). GFA regulates the permselectivity and ultrafiltration of blood. The mechanism by which the integrity of the GFA is compromised and manifest in proteinuria during ischemic stroke remains...

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Vydáno v:Sci Rep
Hlavní autoři: Nakuluri, Krishnamurthy, Nishad, Rajkishor, Mukhi, Dhanunjay, Kumar, Sireesh, Nakka, Venkata P., Kolligundla, Lakshmi P., Narne, Parimala, Natuva, Sai Sampath K., Phanithi, Prakash Babu, Pasupulati, Anil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884642/
https://ncbi.nlm.nih.gov/pubmed/31784544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52872-5
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