Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria

Podocytes are specialized cells of the glomerulus and key component of the glomerular filtration apparatus (GFA). GFA regulates the permselectivity and ultrafiltration of blood. The mechanism by which the integrity of the GFA is compromised and manifest in proteinuria during ischemic stroke remains...

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Udgivet i:Sci Rep
Main Authors: Nakuluri, Krishnamurthy, Nishad, Rajkishor, Mukhi, Dhanunjay, Kumar, Sireesh, Nakka, Venkata P., Kolligundla, Lakshmi P., Narne, Parimala, Natuva, Sai Sampath K., Phanithi, Prakash Babu, Pasupulati, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884642/
https://ncbi.nlm.nih.gov/pubmed/31784544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52872-5
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