Oncolytic HSV infected glioma cells activate NOTCH in adjacent tumor cells sensitizing tumors to gamma secretase inhibition.

PURPOSE: To examine effect of oncolytic herpes simplex virus (oHSV) on NOTCH signaling in CNS tumors. EXPERIMENTAL DESIGN: Bioluminescence imaging, RPPA proteomics, fluorescence microscopy, reporter assays, and molecular biology approaches were used to evaluate NOTCH signaling. Orthotopic glioma- mo...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Otani, Yoshihiro, Yoo, Ji Young, Chao, Samantha, Liu, Joseph, Jaime-Ramirez, Alena Cristina, Lee, Tae Jin, Hurwitz, Brian, Yan, Yuanqing, Dai, Hongsheng, Glorioso, Joseph C., Caligiuri, Michael A., Yu, Jianhua, Kaur, Balveen
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325527/
https://ncbi.nlm.nih.gov/pubmed/32139403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3420
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