Mitochondrial Dysfunction is Associated with an Immune Paralysis Phenotype in Pediatric Sepsis

OBJECTIVE: Immune dysregulation is a defining feature of sepsis, but the role for mitochondria in the development of immunoparalysis in pediatric sepsis is not known. We sought to determine if mitochondrial dysfunction measured in peripheral blood mononuclear cells (PBMCs) is associated with immunop...

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Gepubliceerd in:Shock
Hoofdauteurs: Weiss, Scott L., Zhang, Donglan, Bush, Jenny, Graham, Kathryn, Starr, Jonathan, Murray, Jennifer, Tuluc, Florin, Henrickson, Sarah, Deutschman, Clifford S., Becker, Lance, McGowan, Francis X., Wallace, Douglas C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325426/
https://ncbi.nlm.nih.gov/pubmed/31764621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001486
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