Pharmacokinetic analysis of a novel human EGFRvIII:CD3 bispecific antibody in plasma and whole blood using a high-resolution targeted mass spectrometry approach

Bi-specific single chain antibody fragments (bi-scFv) represent an emerging class of biotherapeutics. We recently developed a fully human bi-scFv (EGFRvIII:CD3 bi-scFv) with the goal of redirecting CD3-expressing T cells to recognize and destroy malignant, EGFRvIII-expressing glioma. In mice, we sho...

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發表在:J Proteome Res
Main Authors: Schaller, Teilo H, Foster, Matthew W, Thompson, J Will, Spasojevic, Ivan, Normantaite, Deimante, Moseley, M. Arthur, Sanchez-Perez, Luis, Sampson, John H
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325320/
https://ncbi.nlm.nih.gov/pubmed/31267741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.9b00145
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