Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial

BACKGROUND: Sickle cell disease (SCD) is a genetic disorder which causes dysfunctional red blood cells (RBC) and is thought to increase requirements for folate, an essential B vitamin, due to increased RBC production and turnover in the disease. High-dose supplementation with 1–5 mg/d folic acid, sy...

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Bibliographic Details
Published in:Trials
Main Authors: Williams, Brock A., McCartney, Heather, Adams, Erin, Devlin, Angela M., Singer, Joel, Vercauteren, Suzanne, Wu, John K., Karakochuk, Crystal D.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Study Protocol
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325072/
https://ncbi.nlm.nih.gov/pubmed/32600389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-020-04540-7
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