Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice

OBJECTIVE: To determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis. APPROACH AND RESULTS: Using a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with the Ldlr(–/...

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發表在:Front Physiol
Main Authors: Yap, Jonathan, McCurdy, Sara, Alcala, Martin, Irei, Jason, Garo, Jan, Regan, Whitney, Lee, Bog-Hieu, Kitamoto, Shiro, Boisvert, William A.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Physiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324766/
https://ncbi.nlm.nih.gov/pubmed/32655419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00714
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