Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice

OBJECTIVE: To determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis. APPROACH AND RESULTS: Using a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with the Ldlr(–/...

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Publicat a:Front Physiol
Autors principals: Yap, Jonathan, McCurdy, Sara, Alcala, Martin, Irei, Jason, Garo, Jan, Regan, Whitney, Lee, Bog-Hieu, Kitamoto, Shiro, Boisvert, William A.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324766/
https://ncbi.nlm.nih.gov/pubmed/32655419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00714
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