Chitinase Inhibition Promotes Atherosclerosis in Hyperlipidemic Mice

Chitinase 1 (CHIT1) is secreted by activated macrophages. Chitinase activity is raised in atherosclerotic patient sera and is present in atherosclerotic plaque. However, the role of CHIT1 in atherosclerosis is unknown. Preliminary studies of atherosclerosis in cynomolgous monkeys revealed CHIT1 to b...

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Detalhes bibliográficos
Main Authors: Kitamoto, Shiro, Egashira, Kensuke, Ichiki, Toshihiro, Han, Xinbing, McCurdy, Sara, Sakuda, Shohei, Sunagawa, Kenji, Boisvert, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702742/
https://ncbi.nlm.nih.gov/pubmed/23685110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.04.003
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