A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors

The immune system works in conjunction with inflammation. Excessive inflammation underlies various human diseases, such as asthma, diabetes and heart disease. Previous studies found that 5-lipoxygenase (5-LOX) plays a crucial role in metabolizing arachidonic acid into inflammatory mediators and is a...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Hsu, Kai-Cheng, HuangFu, Wei-Chun, Lin, Tony Eight, Chao, Min-Wu, Sung, Tzu-Ying, Chen, Yi-Ying, Pan, Shiow-Lin, Lee, Jih-Chin, Tzou, Shey-Cherng, Sun, Chung-Ming, Yang, Jinn-Moon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324578/
https://ncbi.nlm.nih.gov/pubmed/32601404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67420-9
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