The transcription factor GLI1 cooperates with the chromatin remodeler SMARCA2 to regulate chromatin accessibility at distal DNA regulatory elements

The transcription factor GLI1 (GLI family zinc finger 1) plays a key role in the development and progression of multiple malignancies. To date, regulation of transcriptional activity at target gene promoters is the only molecular event known to underlie the oncogenic function of GLI1. Here, we provi...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Safgren, Stephanie L., Olson, Rachel L. O., Vrabel, Anne M., Almada, Luciana L., Marks, David L., Hernandez-Alvarado, Nelmary, Gaspar-Maia, Alexandre, Fernandez-Zapico, Martin E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324497/
https://ncbi.nlm.nih.gov/pubmed/32376693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013268
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