Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice

AMPK is a key regulator at the molecular level for maintaining energy metabolism homeostasis. Mammalian AMPK is a heterotrimeric complex, and its catalytic α subunit exists in 2 isoforms: AMPKα1 and AMPKα2. Recent studies suggest a role of AMPKα overactivation in Alzheimer’s disease–associated (AD-a...

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Publicado en:J Clin Invest
Autores principales: Zimmermann, Helena R., Yang, Wenzhong, Kasica, Nicole P., Zhou, Xueyan, Wang, Xin, Beckelman, Brenna C., Lee, Jingyun, Furdui, Cristina M., Keene, C. Dirk, Ma, Tao
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324210/
https://ncbi.nlm.nih.gov/pubmed/32213711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133982
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