Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis

Germinal center (GC) responses require B cells to respond to a dynamic set of intercellular and microenvironmental signals that instruct B cell positioning, differentiation, and metabolic reprogramming. RHO-associated coiled-coil–containing protein kinase 2 (ROCK2), a serine-threonine kinase that ca...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ricker, Edd, Chinenov, Yurii, Pannellini, Tania, Flores-Castro, Danny, Ye, Chao, Gupta, Sanjay, Manni, Michela, Liao, James K., Pernis, Alessandra B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324193/
https://ncbi.nlm.nih.gov/pubmed/32229726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132414
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