Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load

We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome‐coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treat...

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Dettagli Bibliografici
Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Gonçalves, Antonio, Bertrand, Julie, Ke, Ruian, Comets, Emmanuelle, de Lamballerie, Xavier, Malvy, Denis, Pizzorno, Andrés, Terrier, Olivier, Rosa Calatrava, Manuel, Mentré, France, Smith, Patrick, Perelson, Alan S., Guedj, Jérémie
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323384/
https://ncbi.nlm.nih.gov/pubmed/32558354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12543
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