The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells

Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) is being developed as an iron chelator with selective anticancer activity. We investigated the mechanism whereby Dp44mT kills breast cancer cells, both as a single agent and in combination with doxorubicin. Dp44mT alone induced selective...

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Publicado en:Cancer Res
Main Authors: Rao, V. Ashutosh, Klein, Sarah R., Agama, Keli K., Toyoda, Eriko, Adachi, Noritaka, Pommier, Yves, Shacter, Emily R.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322628/
https://ncbi.nlm.nih.gov/pubmed/19176392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1437
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