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Iron Chelators with Topoisomerase-Inhibitory Activity and Their Anticancer Applications

Significance: Iron and topoisomerases are abundant and essential cellular components. Iron is required for several key processes such as DNA synthesis, mitochondrial electron transport, synthesis of heme, and as a co-factor for many redox enzymes. Topoisomerases serve as critical enzymes that resolv...

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Detalles Bibliográficos
Autor Principal: Rao, V. Ashutosh
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557438/
https://ncbi.nlm.nih.gov/pubmed/22900902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4877
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