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Iron Chelators with Topoisomerase-Inhibitory Activity and Their Anticancer Applications
Significance: Iron and topoisomerases are abundant and essential cellular components. Iron is required for several key processes such as DNA synthesis, mitochondrial electron transport, synthesis of heme, and as a co-factor for many redox enzymes. Topoisomerases serve as critical enzymes that resolv...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Mary Ann Liebert, Inc.
2013
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557438/ https://ncbi.nlm.nih.gov/pubmed/22900902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4877 |
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