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Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons
Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the most important genetic risk factor for Parkinson disease (PD). GCase activity is also decreased in sporadic PD brains and with normal ageing. Loss of GCase activity impairs the autophagy lysosomal pathw...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7322566/ https://ncbi.nlm.nih.gov/pubmed/32391886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa085 |
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