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Mitochondrial dysfunction associated with glucocerebrosidase deficiency
The lysosomal hydrolase glucocerebrosidase (GCase) is encoded for by the GBA gene. Homozygous GBA mutations cause Gaucher disease (GD), a lysosomal storage disorder. Furthermore, homozygous and heterozygous GBA mutations are numerically the greatest genetic risk factor for developing Parkinson'...
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| Published in: | Neurobiol Dis |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Academic Press
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838669/ https://ncbi.nlm.nih.gov/pubmed/26388395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.09.006 |
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