Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features

The immunologic mechanisms promoting eosinophilic granulomatosis with polyangiitis (EGPA) are unclear. To characterize the mechanisms underlying pulmonary EGPA, we examined and compared EGPA paraffin-embedded lung biopsies with normal lung biopsies, using immunostaining, RNA sequencing, and RT-PCR....

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Опубликовано в: :Am J Pathol
Главные авторы: Dong, Zachary M., Lin, Edwin, Wechsler, Michael E., Weller, Peter F., Klion, Amy D., Bochner, Bruce S., Delker, Don A., Hazel, Mark W., Fairfax, Keke, Khoury, Paneez, Akuthota, Praveen, Merkel, Peter A., Dyer, Anne-Marie, Langford, Carol, Specks, Ulrich, Gleich, Gerald J., Chinchilli, Vernon M., Raby, Benjamin, Yandell, Mark, Clayton, Frederic
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322366/
https://ncbi.nlm.nih.gov/pubmed/32251643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.03.005
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