Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features

The immunologic mechanisms promoting eosinophilic granulomatosis with polyangiitis (EGPA) are unclear. To characterize the mechanisms underlying pulmonary EGPA, we examined and compared EGPA paraffin-embedded lung biopsies with normal lung biopsies, using immunostaining, RNA sequencing, and RT-PCR....

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Dong, Zachary M., Lin, Edwin, Wechsler, Michael E., Weller, Peter F., Klion, Amy D., Bochner, Bruce S., Delker, Don A., Hazel, Mark W., Fairfax, Keke, Khoury, Paneez, Akuthota, Praveen, Merkel, Peter A., Dyer, Anne-Marie, Langford, Carol, Specks, Ulrich, Gleich, Gerald J., Chinchilli, Vernon M., Raby, Benjamin, Yandell, Mark, Clayton, Frederic
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322366/
https://ncbi.nlm.nih.gov/pubmed/32251643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.03.005
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