Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features

The immunologic mechanisms promoting eosinophilic granulomatosis with polyangiitis (EGPA) are unclear. To characterize the mechanisms underlying pulmonary EGPA, we examined and compared EGPA paraffin-embedded lung biopsies with normal lung biopsies, using immunostaining, RNA sequencing, and RT-PCR....

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Publicat a:Am J Pathol
Autors principals: Dong, Zachary M., Lin, Edwin, Wechsler, Michael E., Weller, Peter F., Klion, Amy D., Bochner, Bruce S., Delker, Don A., Hazel, Mark W., Fairfax, Keke, Khoury, Paneez, Akuthota, Praveen, Merkel, Peter A., Dyer, Anne-Marie, Langford, Carol, Specks, Ulrich, Gleich, Gerald J., Chinchilli, Vernon M., Raby, Benjamin, Yandell, Mark, Clayton, Frederic
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322366/
https://ncbi.nlm.nih.gov/pubmed/32251643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.03.005
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