Elimination of rNMPs from mitochondrial DNA has no effect on its stability

Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat to genome stability and can result in DNA strand breaks when not removed in a timely manner. However, the presence of a certain level of rNMPs is tolerated in mitochondrial DNA (mtDNA) although aberrant mtDNA rN...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Wanrooij, Paulina H., Tran, Phong, Thompson, Liam J., Carvalho, Gustavo, Sharma, Sushma, Kreisel, Katrin, Navarrete, Clara, Feldberg, Anna-Lena, Watt, Danielle L., Nilsson, Anna Karin, Engqvist, Martin K. M., Clausen, Anders R., Chabes, Andrei
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322039/
https://ncbi.nlm.nih.gov/pubmed/32513727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916851117
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