Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations in enzymes involved in dNTP metabolism. We found that sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1), a deox...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Rentoft, Matilda, Lindell, Kristoffer, Tran, Phong, Chabes, Anna Lena, Buckland, Robert J., Watt, Danielle L., Marjavaara, Lisette, Nilsson, Anna Karin, Melin, Beatrice, Trygg, Johan, Johansson, Erik, Chabes, Andrei
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855590/
https://ncbi.nlm.nih.gov/pubmed/27071091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519128113
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