Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data for mutations in enzymes involved in dNTP metabolism. We found that sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1), a deox...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rentoft, Matilda, Lindell, Kristoffer, Tran, Phong, Chabes, Anna Lena, Buckland, Robert J., Watt, Danielle L., Marjavaara, Lisette, Nilsson, Anna Karin, Melin, Beatrice, Trygg, Johan, Johansson, Erik, Chabes, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855590/
https://ncbi.nlm.nih.gov/pubmed/27071091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519128113
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