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Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin
A eukaryotic chromosome relies on the function of multiple spatially distributed DNA replication origins for its stable inheritance. The spatial location of an origin is determined by the chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is assembled onto...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7322022/ https://ncbi.nlm.nih.gov/pubmed/32513739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004664117 |
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