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Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin

A eukaryotic chromosome relies on the function of multiple spatially distributed DNA replication origins for its stable inheritance. The spatial location of an origin is determined by the chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is assembled onto...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hoggard, Timothy, Müller, Carolin A., Nieduszynski, Conrad A., Weinreich, Michael, Fox, Catherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322022/
https://ncbi.nlm.nih.gov/pubmed/32513739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004664117
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