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Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin

A eukaryotic chromosome relies on the function of multiple spatially distributed DNA replication origins for its stable inheritance. The spatial location of an origin is determined by the chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is assembled onto...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Hoggard, Timothy, Müller, Carolin A., Nieduszynski, Conrad A., Weinreich, Michael, Fox, Catherine A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322022/
https://ncbi.nlm.nih.gov/pubmed/32513739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004664117
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