Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins

Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2, and at some heterochromatic loci also by the nucle...

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發表在:PLoS Genet
Main Authors: Hoggard, Timothy A., Chang, FuJung, Perry, Kelsey Rae, Subramanian, Sandya, Kenworthy, Jessica, Chueng, Julie, Shor, Erika, Hyland, Edel M., Boeke, Jef D., Weinreich, Michael, Fox, Catherine A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991416/
https://ncbi.nlm.nih.gov/pubmed/29795547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007418
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