Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins

Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2, and at some heterochromatic loci also by the nucle...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Hoggard, Timothy A., Chang, FuJung, Perry, Kelsey Rae, Subramanian, Sandya, Kenworthy, Jessica, Chueng, Julie, Shor, Erika, Hyland, Edel M., Boeke, Jef D., Weinreich, Michael, Fox, Catherine A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991416/
https://ncbi.nlm.nih.gov/pubmed/29795547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007418
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