Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins

Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2, and at some heterochromatic loci also by the nucle...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hoggard, Timothy A., Chang, FuJung, Perry, Kelsey Rae, Subramanian, Sandya, Kenworthy, Jessica, Chueng, Julie, Shor, Erika, Hyland, Edel M., Boeke, Jef D., Weinreich, Michael, Fox, Catherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991416/
https://ncbi.nlm.nih.gov/pubmed/29795547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007418
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