RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit

The 90 kDa Ribosomal S6 Kinase (RSK) drives cell proliferation and survival in cancers, although its oncogenic mechanism has not been well characterized. Phosphorylated level of RSK (T573) was increased in acute myeloid leukemia (AML) patients and associated with poor survival. To examine the role o...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Chae, Hee-Don, Dutta, Ritika, Tiu, Bruce, Hoff, Fieke W., Accordi, Benedetta, Serafin, Valentina, Youn, Minyoung, Huang, Min, Sumarsono, Nathan, Davis, Kara L., Lacayo, Norman J., Pigazzi, Martina, Horton, Terzah M., Kornblau, Steven M., Sakamoto, Kathleen M.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2020
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321696/
https://ncbi.nlm.nih.gov/pubmed/32637030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27630
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