RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit

The 90 kDa Ribosomal S6 Kinase (RSK) drives cell proliferation and survival in cancers, although its oncogenic mechanism has not been well characterized. Phosphorylated level of RSK (T573) was increased in acute myeloid leukemia (AML) patients and associated with poor survival. To examine the role o...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chae, Hee-Don, Dutta, Ritika, Tiu, Bruce, Hoff, Fieke W., Accordi, Benedetta, Serafin, Valentina, Youn, Minyoung, Huang, Min, Sumarsono, Nathan, Davis, Kara L., Lacayo, Norman J., Pigazzi, Martina, Horton, Terzah M., Kornblau, Steven M., Sakamoto, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321696/
https://ncbi.nlm.nih.gov/pubmed/32637030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27630
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