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The Reversibility of Mitotic Exit in Vertebrate Cells

A guiding hypothesis for cell cycle regulation asserts that regulated proteolysis constrains the directionality of certain cell cycle transitions1, 2. We have tested this hypothesis for mitotic exit, which is regulated by degradation of the Cdk1 activator, cyclin B3-5. Application of chemical Cdk1 i...

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Detalhes bibliográficos
Main Authors: Potapova, Tamara A., Daum, John R., Pittman, Bradley D., Hudson, Joanna R., Jones, Tara N., Satinover, David L., Stukenberg, P. Todd, Gorbsky, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1513549/
https://ncbi.nlm.nih.gov/pubmed/16612388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04652
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