Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

OBJECTIVE: Natural killer (NK) cells play a critical role in the innate antitumor immune response. Recently, NK cell dysfunction has been verified in various malignant tumors, including hepatocellular carcinoma (HCC). However, the molecular biological mechanisms of NK cell dysfunction in human HCC a...

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Bibliografske podrobnosti
izdano v:Mol Cancer
Main Authors: Zhang, Peng-Fei, Gao, Chao, Huang, Xiao-Yong, Lu, Jia-Cheng, Guo, Xiao-Jun, Shi, Guo-Ming, Cai, Jia-Bin, Ke, Ai-Wu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7320583/
https://ncbi.nlm.nih.gov/pubmed/32593303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01222-5
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