A metabolic pathway for bile acid dehydroxylation by the gut microbiome

The gut microbiota synthesize hundreds of molecules, many of which are known to impact host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at ~500 μM and are known to block C. difficile growth(1), promo...

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Publicado en:Nature
Autores principales: Funabashi, Masanori, Grove, Tyler L., Wang, Min, Varma, Yug, McFadden, Molly E., Brown, Laura C., Guo, Chunjun, Higginbottom, Steven, Almo, Steven C., Fischbach, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319900/
https://ncbi.nlm.nih.gov/pubmed/32555455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2396-4
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