Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

Clostridium scindens, biotransforms primary bile acids into secondary bile acids, is correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study was to determine how C. scindens regulates C. difficile growth in vitro and if these interactions might relate to the...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Kang, Jason D., Myers, Christopher J., Harris, Spencer C., Kakiyama, Genta, Lee, In-Kyoung, Yun, Bong-Sik, Matsuzaki, Keiichi, Furukawa, Megumi, Min, Hae-Ki, Bajaj, Jasmohan S., Zhou, Huiping, Hylemon, Phillip B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338514/
https://ncbi.nlm.nih.gov/pubmed/30482679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.10.003
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