Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association

HIV-1 Rev protein mediates nuclear export of un-spliced and partially spliced viral RNAs for production of viral genomes and structural proteins. Rev assembles on a 351-nt Rev response element (RRE) within viral transcripts and recruits host export machinery. Small (<40-nt) RNA aptamers that comp...

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Bibliographic Details
Published in:Structure
Main Authors: Dearborn, Altaira D., Eren, Elif, Watts, Norman R., Palmer, Ira W., Kaufman, Joshua D., Steven, Alasdair C., Wingfield, Paul T.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319042/
https://ncbi.nlm.nih.gov/pubmed/30017564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.06.001
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