Designer Receptors for Nucleotide‐Resolution Analysis of Genomic 5‐Methylcytosine by Cellular Imaging

We report programmable receptors for the imaging‐based analysis of 5‐methylcytosine (5mC) in user‐defined DNA sequences of single cells. Using fluorescent transcription‐activator‐like effectors (TALEs) that can recognize sequences of canonical and epigenetic nucleobases through selective repeats, we...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Muñoz‐López, Álvaro, Buchmuller, Benjamin, Wolffgramm, Jan, Jung, Anne, Hussong, Michelle, Kanne, Julian, Schweiger, Michal R., Summerer, Daniel
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318601/
https://ncbi.nlm.nih.gov/pubmed/32167219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202001935
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