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In Situ Acetaldehyde Synthesis for Carboligation Reactions

The enzyme 4‐oxalocrotonate tautomerase (4‐OT) can promiscuously catalyze various carboligation reactions using acetaldehyde as a nucleophile. However, the highly reactive nature of acetaldehyde requires intricate handling, which can impede its usage in practical synthesis. Therefore, we investigate...

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Bibliografiske detaljer
Udgivet i:Chembiochem
Main Authors: Biewenga, Lieuwe, Kunzendorf, Andreas, Poelarends, Gerrit J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318290/
https://ncbi.nlm.nih.gov/pubmed/31868962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900666
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