Synthesis of Small‐Molecule Fluorescent Probes for the In Vitro Imaging of Calcium‐Activated Potassium Channel K(Ca)3.1

Small‐molecule probes for the in vitro imaging of K(Ca)3.1 channel‐expressing cells were developed. Senicapoc, showing high affinity and selectivity for the K(Ca)3.1 channels, was chosen as the targeting component. BODIPY dyes 15–20 were synthesized and connected by a Cu(I)‐catalyzed azide–alkyne [3...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Brömmel, Kathrin, Maskri, Sarah, Maisuls, Ivan, Konken, Christian Paul, Rieke, Marius, Pethő, Zoltan, Strassert, Cristian A., Koch, Oliver, Schwab, Albrecht, Wünsch, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318252/
https://ncbi.nlm.nih.gov/pubmed/32097518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202001201
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