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Size‐dependent secretory protein reflux into the cytosol in association with acute endoplasmic reticulum stress

Once secretory proteins have been targeted to the endoplasmic reticulum (ER) lumen, the proteins typically remain partitioned from the cytosol. If the secretory proteins misfold, they can be unfolded and retrotranslocated into the cytosol for destruction by the proteasome by ER‐Associated protein De...

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Pubblicato in:Traffic
Autori principali: Lajoie, Patrick, Snapp, Erik L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons A/S 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317852/
https://ncbi.nlm.nih.gov/pubmed/32246734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12729
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